Aprezo (Apremilast) is not an injection, cream, or biologic. It is a drug for the treatment of patients with moderate to severe plaque psoriasis. Many people assume that psoriasis Vulgaris is just a skin disorder, but it actually develops in the body. So it’s important to keep this in mind. Psoriasis Vulgaris is associated with excessive inflammation in the body. Laboratory studies have shown that an enzyme located inside the cell called phosphodiesterase 4 (PDE4) contributes to this inflammation.
The active ingredient in APREZO tablets is apremilast. Apremilast is a phosphodiesterase 4 (PDE4) inhibitor, which means that it acts inside inflammatory cells to reduce PDE4 activity. Decreased PDE4 activity is thought to help reduce overactive inflammation that occurs in people with plaque psoriasis. Less inflammation may reduce the symptoms of plaque psoriasis. This means less redness, thickness, and scale of plaque.
Aprezo is also approved for the treatment of adult patients with active psoriatic arthritis. Psoriatic arthritis usually occurs after the age of 30 and causes joint stiffness, pain, and swelling, resulting in real disability. Treatment with Aprezo can relieve pain, reduce swelling, keep joints functioning properly, and prevent joint damage.
How to take it?
Aprezo tablet is available as a 30 milligram (mg) tablet. When you first start taking Aprezo, your doctor will probably gradually increase your dose over a 5-day schedule as follows:
Day 1:
Morning: 10 mg
Day 2:
Morning: 10 mg
Evening: 10 mg
Day 3:
Morning: 10 mg
Evening: 20 mg
Day 4:
Morning: 20 mg
Evening: 20 mg
Day 5:
Morning: 20 mg
Evening: 30 mg
From the 6th day onward, it will be administered once and twice in the morning and evening. The reason for this is to reduce nausea and diarrhea associated with the first treatment. Then you will stay at this dose. Aprezo 30 mg tablet can be taken with or without food-one in the morning and one in the evening. Do not crush or chew the tablets. Be sure to take as directed by your doctor.
Clinical trials have shown that about 30% of patients have a 20% reduction in the number of painful and swollen joints after 4 months. It is a chronic drug that is used continuously as long as it is effective and well-tolerated.
What else should you know?
Are you thinking of giving birth to a baby? Limited information is available on the possible effects of Apremilast during pregnancy. Women who are pregnant or plan to become pregnant should not use this medicine. Men should not conceive women during treatment and for 3 months after discontinuing this drug. Men should use condoms throughout this time.
Keep track of your weight while you are taking this medicine, and tell your doctor about any major weight loss.
It is also unknown whether apremilast is excreted in breast milk. If you are nursing, use it with caution.
If you have kidney disease, contact your rheumatologist as the dose of apremilast should be adjusted for patients with severe renal dysfunction.
Other medications, such as prescription and over-the-counter medications, vitamins, and herbal products, may interact with this arthritis medication. Talk to each of your health care providers about all the medicines you are using now and all the medicines you have started or stopped using.
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